Redox regulation and the metabolic syndrome
نویسندگان
چکیده
منابع مشابه
Redox regulation in metabolic programming and inflammation
Energy metabolism and redox state are intrinsically linked. In order to mount an adequate immune response, cells must have an adequate and rapidly available energy resource to migrate to the inflammatory site, to generate reactive oxygen species using NADPH as a cofactor and to engulf bacteria or damaged tissue. The first responder cells of the innate immune response, neutrophils, are largely d...
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Reactive oxygen species (ROS) production and the resultant shift in the cellular redox state can exert a biphasic effect on cellular functions such as survival, migration or proliferation. At high levels, ROS can induce broad DNA and protein damage which can result in cell death, but at lower levels ROS act as signaling molecules that sustain proliferation or activate specific stress-response p...
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Macrophage plasticity is an important feature of these innate immune cells. Macrophage phenotypes are divided into two categories, the classically activated macrophages (CAM, M1 phenotype) and the alternatively activated macrophages (AAM, M2 phenotype). M1 macrophages are commonly associated with the generation of proinflammatory cytokines, whereas M2 macrophages are anti-inflammatory and often...
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Objectives: The relation of metabolic syndrome components, insulin resistance and leptin has been studied in elderly women. Methods & Materials: In this cross sectional study, among 225 subjects≥60 year old who were residents of Kahrizak Charity Foundation, 133 (56 men & 77 women) were selected by cluster random sampling. Fasting serum TG, Total Cholesterol, HDL, and leptin levels were measu...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2011
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2011.58